Investigation of Effectiveness of Different Exercise Types, and Their Therapeutic Effect Mechanisms and the Roles of Motivational Interview in the Treatment of Non-Alcoholic Fatty Liver Disease

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this 12-week clinical trial is to investigate the effectiveness of different exercise types in treating Non-Alcoholic Fatty Liver Disease (NAFLD) and to explore their impact on myokine levels associated with lipid metabolism. The main questions it aims to answer are: 1. How does the type and dose of exercise affect the treatment of NAFLD? 2. What is the influence of exercise interventions in NAFLD treatment on myokine levels related to lipid metabolism? 3. How does motivational interviewing contribute to lifestyle modification in the treatment of NAFLD? Participants in this study will engage in assigned exercise routines randomly, including HIIT, resistance training, or FATmax exercises. Additionally, motivational interviewing techniques will be employed to assess their impact on lifestyle changes. Researchers will compare the outcomes among the different exercise groups, along with a control group receiving only standard care for NAFLD. This comparison aims to determine the respective effects of these interventions on both NAFLD and associated myokine levels.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 50
Healthy Volunteers: f
View:

• Have received a diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

• Age between 25 and 50 years old

• Use of smartphone

• Fall into category A or B according to the American Heart Association Risk Assessment Criteria

Locations
Other Locations
Turkey
Yeditepe University
RECRUITING
Istanbul
Contact Information
Primary
Mehtap Kaçar, MD, PhD, Prof
mehtap.kacar@yeditepe.edu.tr
+90 (216) 578 00 00
Backup
Meltem Yalçın Oğuz, MSc, Pt
meltem.yalcin@yeditepe.edu.tr
+90 (216) 578 00 00
Time Frame
Start Date: 2024-01-05
Estimated Completion Date: 2024-10-15
Participants
Target number of participants: 144
Treatments
No_intervention: Control Group
This group will consist of individuals with liver fat accumulation under standard care and no exercise intervention will be implemented.
Experimental: Fatmax Exercise Group
Individuals with liver fat accumulation under standard care will have their Fatmax values calculated and an exercise prescription will be designed accordingly.
Experimental: Fatmax Exercise and Motivational Interviewing Group
In addition to the prescription of Fatmax exercise for individuals with liver fat accumulation under standard care, motivational interviewing principles will be applied.
Experimental: HIIT Group
Individuals with liver fat accumulation under standard care will be provided with a High-Intensity Interval Training (HIIT) exercise prescription.
Experimental: HIIT and Motivational Interviewing Group
In addition to formulating a High-Intensity Interval Training (HIIT) exercise prescription for individuals with liver fat accumulation under standard care, motivational interviewing principles will be applied.
Experimental: Resistance Exercise Group
Individuals with liver fat accumulation under standard care will be provided with a resistance exercise prescription.
Experimental: Resistance Exercise and Motivational Interviewing Group
In addition to formulating a resistance exercise prescription for individuals under standard care with liver fat accumulation, motivational interviewing principles will be applied.
Related Therapeutic Areas
Sponsors
Leads: Yeditepe University
Collaborators: The Scientific and Technological Research Council of Turkey

This content was sourced from clinicaltrials.gov

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